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陈蔚文副教授

2017-4-23 21:06:53

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详细介绍

陈蔚文,山东大学,基础医学院生物化学与分子生物学系,副教授

 

教育经历:

2005/09-2008/06山东大学,基础医学院生物化学与分子生物学系,博士,导师:张建业

1998/09-2001/06,山东大学,基础医学院生物化学与分子生物学系,硕士,导师:张建业

1991/09-1996/06,山东大学,医学院临床医学系,学士

 

科研与学术工作经历:

1.2007/10-至今,山东大学,生物化学与分子生物学系,副教授

2.2002/10-2007/09,山东大学,生物化学与分子生物学系,讲师

3.2001/07-2002/09,山东大学,生物化学与分子生物学系,助教

4.1996/07-1998/08,山东大学,生物化学与分子生物学系,助教

 

主持或参加科研项目(课题)及人才计划项目情况

迄今主持国家自然科学基金项目3项(2项已结题),山东省博士基金1项(已结题),山东省自然科学基金1项,第一作者及通讯作者发表SCI文章10篇。

课题:

1)         国家自然科学基金面上项目,p53对前列腺癌细胞中抑丝酶基因maspin的表达调控,3037156418万元,2004.01-2006.12

2)         山东省优秀中青年科学家科研奖励基金计划,两个肺癌治疗新靶点:Wnt信号通路和miRNA Let-7a-2的相互关系研究,BS2009SW0425万元,2009.12-2012.12

3)         国家自然科学基金面上项目,lincRNA-ETS1-2上调癌基因ETS-1表达促进雄激素非依赖性前列腺癌演进的机制,8137276455万元,2014.01-2017.12

4)         山东省自然科学基金面上项目,驱动蛋白KIF4A促进肺癌顺铂耐药的分子机制研究, 项目名称 驱动蛋白KIF4A促进肺癌顺铂耐药的分子机制研究,ZR2018MH03012.00万元,2018.03-2021.06

5)         国家自然科学基金面上项目,NACB通过上调干细胞关键因子BMI-1诱导干细胞样表型促进侵袭性前列腺癌的恶性进展,8197241355万元,2020.01-2023.12

 

论文:

1.         Ying Zhang (#); Li-Na Wang (#); Ya-Ni Ling; Yuan-Xin Xing; Yu Shi; Jian, Zhao; Wei-Wen Chen (*); Bo Han. The novel long noncoding RNA LOC283070 is involved in the transition of LNCaP cells into androgen‑independent cells via its interaction with PHB2. Asian Journal of Andrology, 2018.6.19, 20(5):511~5

2.         Lina Wang#, Yani Lin, Hui Meng, Chunyan Liu, Jing Xue, Qi Zhang, Chaoyang Li, Pengju Zhang, Fuai Cui, Weiwen Chen*, Anli Jiang, Long non-coding RNA LOC283070 mediates the transition of LNCaP cells into androgen-independent cells possibly via CAMK1D, Am J Transl Res 2016;8(12):5219-5234

3.         Yani Lin#, Jian Zhao#, Xiaoyan Hu, Lina Wang, Liming Liang and Weiwen Chen*, Transcription factor CCAAT/enhancer binding protein alpha up‑regulates microRNA let‑7a‑1 in lung cancer cells by direct binding, Cancer Cell International, 2016, 16:17

4.         Lina Wang#, Chunyan Liu, Chaoyang Li, Jing Xue, Shihu Zhao, Panpan Zhan, Yani Lin, Pengju Zhang, Anli Jiang, Weiwen Chen*, Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells, Gene,2015, 572(2):252-8

5.         Kai-Ze Zhong#, Wei-Wen Chen#, Xiao-Yan Hu, An-Li Jiang, Jian Zhao*, Clinicopathological and prognostic significance of microRNA-107 in human non small cell lung cancer, Int J Clin Exp Pathol, 2014,7(7):4545-4551

6.         Li-Na Wang#, Wei-Wen Chen#, Ju Zhang, Chao-Yang Li, Chun-Yan Liu, Jing Xue, Peng-Ju Zhang and An-Li Jiang*, The miRNA let-7a1 inhibits the expression of insulin-like growth factor 1 receptor (IGF1R) in prostate cancer PC-3 Cells, Asian J Androl, 2013, 15(6):753-8

7.         Jian Zhao#, Nana Ni#, Chang Liu, Pengju Zhang, Yang Yu, Zhaobo Chen, Weiwen Chen*and Anli Jiang, Cloning and characterization of the 5' flanking region of microRNA let-7a-1/let-7f-1 gene cluster in human lung cancer cell, African Journal of Biotechnology, 2011, 10(46): 9233-9241

8.         Weiwen Chen#,Weifang Wu#,Jian Zhao,Chunxiao Yu,Wenwen Liu,Anli Jiang*,Jianye Zhang*, Molecular cloning and preliminary analysis of the human a-methylacyl-CoA racemase promoter, Mol Biol Rep, 2009, 36:423-430

9.         Mei-lan H#, Wei-wen CHEN#, Peng-ju ZHANG, An-li JIANG, Wei FAN, Hui-qing YUAN, Wen-wen LIU, Jian-ye ZHANG*,Gum mastic increases maspin expression in prostate cancer cells,Acta Pharmacol Sin, 2007, 28 (4): 567–572

10.     CHEN Weiwen#, ZHANG Jianye*, Charles Y F Young, ZHANG Lianying, CHEN Liucun & ZHAO Jian, The RFA regulatory sequence-binding protein the promoter of prostate-specific antigen gene,Sci China C Life Sci,2003,46(2):184-93






 

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